Media Rights Capital. Baby Driver receives ACE nomination for Best Edited Feature Film. Films such as “Blade Runner 2. Dunkirk” and “Baby Driver” joined television series like “Black- ish,” “Better Call Saul” and “The Handmaid’s Tale” as nominees for American Cinema Editors’ 6. The HUGE List Of Free Knitting Patterns for Boys including hats, sweaters, blankets, toys and more! Featuring Batman, Iron Man, Minions, Spiderman patterns. The Orville is a live-action Science Fiction Comedy/Dramedy television series created by, and starring, Seth MacFarlane in an homage to classic Star Trek. Adam Smith FRSA (16 June 1723 NS (5 June 1723 OS) – 17 July 1790) was a Scottish economist, philosopher, and author. He was a moral philosopher, a pioneer of. ACE Eddie Awards Wednesday.“Blade Runner” and “Dunkirk” were nominated in the dramatic film category along with “Molly’s Game,” “The Post” and “The Shape of Water.” “Baby Driver” was recognized alongside “Get Out,” “I, Tonya,” “Lady Bird” and “Three Billboards Outside Ebbing, Missouri” in the comedy field. The “Three Billboards” nomination is noteworthy as the film competes in the drama category at the Golden Globes this year, yet it has been situated as a comedy with ACE. Other TV series nominated include “Crazy Ex- Girlfriend,” “Portlandia,” “Will & Grace,” “Curb Your Enthusiasm,” “Fargo” and “Game of Thrones,” while miniseries/TV movies in the mix include “Feud,” “Genius” and “The Wizard of Lies.” HBO’s “Big Little Lies” was chalked up in the drama series category. On the film critics circuit so far this year, “Baby Driver” and “Dunkirk” have reaped the most kudos. Winners will be revealed at the 6. ACE Eddie Awards on Friday, Jan. See the full list of nominees at Variety. Baby Driver Wins Three Los Angeles Online Film Critics Awards. The Los Angeles Online Film Critics Society has unveiled its inaugural awards, naming Guillermo del Toro’s The Shape of Water its Best Picture of 2. The Fox Searchlight pic had four wins overall, including Best Director, Best Actress for Sally Hawkins and Best Score for Alexandre Desplat. Greta Gerwig’s Lady Bird was voted Best Indie Film, with Gerwig winning the group’s Best Female Director award and Saoirse Ronan taking the Best Actor or Actress 2. Under honor. The group split its top movie awards among several genres: Wonder Woman is Best Blockbuster, The Big Sick is Best Comedy or Musical, Baby Driver is Best Action/War, and Get Out is Best Sci- Fi/Horror. See the full list of winners at Deadline. ![]() How 'Baby Driver' Struck the "Right Balance" of Sounds to Create Car- Chase Drama. Sound editing and sound mixing are two separate categories in the Oscar race, but many laypeople would quickly admit that they don't exactly know the difference. I understand how some people would be confused by the two as the lines can be very hard to distinguish," admits Julian Slater, who served as supervising sound editor, designer and rerecording mixer on Baby Driver. Sound pros often reach for metaphors, such as cooking, to explain the difference: Sound editing could be likened to preparing the ingredients, and mixing is when everything comes together to prepare the dish. Pros from three films reveal their recipes for awards- contending sound. For Edgar Wright's bank robbery action film starring Ansel Elgort, the 3. For Slater, "each sound effect had to be vetted to work both musically and cinematically." For example, to incorporate the car skids so that they became part of the music, Slater and his team had to pitch and edit them way beyond what one would normally do. However, what you are left with may sound great musically but just not believable from a cinematic point of view," he adds. Both of these boxes had to be checked for that particular sound effect to make it into the movie. When it came to the mix, we then had to figure out the right balance of all these sounds so that it felt like a continuous piece of music."The movie's sound is heard through the perspective of getaway driver Baby (Elgort), who constantly listens to music to drown out his tinnitus. We wanted the audience to have the same auditory experience that he was having, good and bad," says Slater. When he's listening to the music he loves, we envelop the audience in the soundtrack." To have the audience experience tinnitus, the team portrayed the sound in a variety of ways, from held strings in Steven Price's score to a set of high tonal frequencies. 'Alo posta, javi jel' to Crna Gora, Bar sada cu vi da objasnim u cemu je stvar Odje je Beograd zove Boro, Djokov sin u narodu poznat kao zenski dusmanin.As Baby gets more stressed, the tinnitus increases."Read the full article at Hollywoodreporter. Laura Linney and Jason Bateman Receive SAG Award Nominations for Ozark. Nominations for the 2. Screen Actors Guild Awards were announced on Wednesday morning. Olivia Munn and Niecy Nash revealed the nominees from the Pacific Design Center in West Hollywood. TNT, TBS, and tru. TV aired the announcement, which was also available to stream online, starting at 7 a. PT/1. 0 a. m ET. Presenters were joined by SAG- AFTRA president Gabrielle Carteris, SAG Awards committee chair Jo. Beth Williams, and SAG Awards committee member Elizabeth Mc. Laughlin.“Big Little Lies,” “Stranger Things,” and “GLOW” each scored four nods on the TV side, while “Three Billboards Outside Ebbing, Missouri” landed four nominations and “Lady Bird” received three for film. Kristen Bell will host the SAG Awards on Jan. The ceremony, recognizing top performances in television and film, will air live on both TNT and TBS at 8 p. ET. See the full list of nominees at Variety. The 7 Places to Buy Party Supplies in Singapore. Be it personal celebrating events like Birthday, Bachelorette, and Wedding or festive occasions like New Year, Christmas, Easter, Halloween, Mid Autumn Festival, and Hari Raya Puasa, Singapore’s party supplies stores have got you covered. Party planners can get from- A- to- Z stuff for your party from the below listed shops. See also: The 5 Best Online Stores for Party Supplies in Singapore.
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Laser Dermatology - treatments. Skin blemishes that are present at birth or appear soon after are generally referred to as "birthmarks". These may be red or brown and represent an overgrowth of superficial blood vessels or pigment cells. Medicines information from Great Ormond Street Hospital on treating small infantile haemangiomas with topical timolol. Action Through Enterprise ATE is changing the lives of children and adults living in the poorest parts of Ghana. Through provision of free school meals, support for. Angiomas in adults. Authoritative facts about the skin from DermNet New Zealand. In this article Dr. Ronald Hoffman discusses the causes of ulcers, & dietary suggestions when living with ulcers. Learn how you can improve your health today! 20.1 IME List MedDRA Code SOC Name PT Name Comment Primary SOC Change 10078862 Blood and lymphatic system disorders Hyperleukocytosis X 10078778 IDH differentiation. Correspondence. Propranolol for Severe Hemangiomas of Infancy. N Engl J Med 2008; 358:2649-2651 June 12, 2008 DOI: 10.1056/NEJMc0708819. Laser Birthmark Removal Treatment. Skin blemishes that are present at birth or appear soon after are generally referred to as "birthmarks". These may be red or brown. The treatment of these birthmarks depends on the type of lesion. Port wine stain birthmarks. These flat red marks are present at birth and will not disappear over time. Until recently, these disfiguring birthmarks were life- long problems which have the potential to thicken and become more unsightly with ageing. As the foundation director of the laser unit at the Royal Children's Hospital, Dr Bekhor has been using laser therapy to fade and, in many cases, remove these birthmarks in young children before they start school. This has enormous social implications in an unkind world. The Candela Vbeam Perfecta™ pulsed dye laser is the treatment of choice for these birthmark lesions. Young children can be treated at the Royal Children's Hospital. Laser Dermatology offers the same laser treatments to Adults who have missed out on early intervention. We have the Perfecta laser, the Flex™ IPL (intense pulsed light) and Excell. V™ laser long pulsed Nd YAG laser. ![]() Epidemiology. Shoulder pain is the third most common cause of musculoskeletal consultation in primary care. 1% of adults with new shoulder pain consult their GP each. ENT RED FLAGS EAR • Persistent unilateral hearing loss/tinnitus • discharging ears [espec in immunocompromised =malignant otitis externa] • Pain. Medicines information from Great Ormond Street Hospital on treating haemangiomas with propranolol. The Dermatology Laser Unit at the Royal Children's Hospital is the only specialist paediatric centre in Victoria that can offer treatment under safe general anaesthesia for children. Haemangiomas (Strawberry birthmarks)These are flat red birthmarks that are not present immediately at birth but appear in the first weeks of life. They birthmarks often grow and thicken rapidly and, in extreme circumstances, ulcerate. This type of haemangioma will usually disappear by 1. Again, Candela Perfecta™ pulsed dye laser is the treatment of choice to arrest the growth and thickening of these birthmarks. Laser Treatment is only successful on flat lesions, so early diagnosis and intervention of these haemangiomas is extremely important. Usually a paediatrician or Infant Welfare nurse will identify the early signs of birthmarks and refer babies to Melbourne dermatologist Dr Philip Bekhor, who is an experienced expert in laser treatment of birthmarks. If a haemangioma appears on an eyelid, nose, lip or extensively over the face, this should be regarded as a medical emergency requiring urgent medical intervention. The "gold standard" of treatment is oral or topical "beta- blocker" medication. News and Articles for more information on this treatment). In selected cases where the birthmark is still flat, laser may be used. Infants presenting with these birthmarks are usually managed by the team at the Children's Hospital where the combined expertise of medical specialists, including laser dermatologists and paediatricians, achieves the best outcome. Spider naevi. These small annoying red spots often appear in young children and can lead to teasing at school. They are caused by the dilation of a small arteriole close to the skin. Fortunately, they respond very well to laser treatment with the pulsed dye laser and usually only a single laser treatment is necessary. Brown birthmarks. Like vascular (red) birthmarks, some of these are present at birth while others appear over time. The skin colour- producing cell is known as a melanocyte and the brown colour produced is referred to as melanin. Brown birthmarks are caused by a proliferation of melanocyte cells or an increase in melanin production in a specific area. The laser treatment of choice is Q- Switched Laser (Ruby, YAG or Alexandrite). Café au lait (flat, milk coffee coloured marks) birthmarks respond in 5. Naevus of Ota and naevus of Ito usually respond well, as does Hori's naevus. Becker's naevus, unfortunately, only responds to laser treatment in a minority of cases. Usually a laser test treatment is carried out to establish whether the lesion is responsive to laser removal. The Laser Unit at the Royal Children's Hospital is the only location in Australia that can offer extensive laser treatment of brown birthmarks on children under general anaesthetic. Congenital Melanocytic Naevi are essentially moles that appear at birth. Sometimes they can be extremely large and are known as "Bathing Trunk Naevi". These lesions may sometimes respond to laser treatment. At Laser Dermatology, most birthmarks are subjected to a test treatment to establish responsiveness before proceeding to full laser treatment. In most cases, multiple laser treatments are required. As with other lasers, the sensation is that of a flick with a rubber band. Treatment under safe paediatric general anaesthetic for children with extensive birth marks is available at the Laser Unit, Department of Dermatology at the Royal Children's Hospital. An important note about professional experience. There are many laser systems used to treat birthmarks - some more appropriate than others. However, as important as the technology is the competence and experience of the medical professional operating the machine. No one laser is the answer for every problem or skin type. Ulcers | Natural Health | Hoffman Center. Share: October 4, 2. By Dr. Ronald Hoffman. Up to 1. 2 percent of Americans have ulcers at some point in life. Peptic ulcers are sores found in the lining of your stomach or of your duodenum, the upper portion of your small intestine. Duodenal ulcers are the more common, accounting for 3/4 of all cases. Ulceration occurs when the stomach’s or duodenum’s mucosal lining cannot withstand the corrosive action of gastric juice, which your stomach’s lining secretes to break down your meals. Gastric juice, which consists of hydrochloric acid and an enzyme, pepsin, which breaks down protein, can digest any living tissue, including your stomach and duodenum. Normally, both your stomach and duodenum are bathed constantly in gastric acid. But protective mechanisms, including the work of prostaglandins, which govern secretion of mucus from your stomach lining, and your food and saliva’s ability to dilute acid, prevent your stomach from digesting itself. In the past few years, medical thinking about peptic ulcers has changed dramatically: Doctors used to think that having ulcers meant that you produced too much gastric acid. Some people with duodenal ulcers do secrete abnormal amounts of acid, but as many as half do not. And in most cases of gastric or stomach ulcers, acid is normal or even reduced. Now researchers recognize that the causes are more complex and may include a failure of your stomach’s cytoprotection. Other contributing factors may be smoking, alcohol, family predisposition, emotional stress and even bacterial infection or the use of common pain- killing medications such as aspirin. Peptic ulcers are chronic; they may recur at any time. Ulcers are rarely a prelude to cancer, but some ulcers, especially gastric ulcers, are an erosion of the stomach due to cancer. Even if ulcers are not cancerous, they can be very dangerous. An untreated ulcer can cause intestinal obstruction or rapid bleeding into your intestinal tract, which can be fatal. And like a ruptured appendix, an ulcer that erodes all the way through the wall of your stomach or duodenum can cause peritonitis. If you have an ulcer and any of these complications set in, you may need surgery. Thankfully, because of new drugs, ulcer surgery has become relatively rare. Certainly there are some steps you can take to avoid such a dire solution to ulcers. Fueling an ulcer’s fire. The first sign of an ulcer may be a good deal of belching and bloating, so that you may think you have a bad case of gas pains. But the pain becomes sharp and constant, and sometimes feels like a “stitch” somewhere between your navel and the base of your breastbone. It may be particularly gnawing between meals or when your stomach is empty; you feel some relief after you eat something–but perplexingly, the reverse also can be true. Even after an ulcer heals you may feel pain in that portion of your gut if you eat or drink anything that irritates your stomach lining. One woman in her early 3. As far as we know, moderate consumption of alcohol and caffeine doesn’t cause ulcers. But alcohol and caffeine do stimulate acid secretion in your stomach, as does decaffeinated coffee. Caffeine also blocks production of prostaglandins, weakening your stomach’s cytoprotection. So any of these ingredients of popular beverages can exacerbate an ulcer you already have. Surprisingly, so can milk, which used to be a mainstay of ulcer patients’ diets. Initially, milk does neutralize stomach acid–but then, acting on the rebound, it prompts the production of even more. Stress may not cause ulcers as frequently as most doctors once thought, but it can increase pain or flare- ups. One Australian study found that duodenal ulcers frequently recur when patients go through marital separation or divorce. Genes and gender also may contribute to ulcers: You’re three times as likely to get an ulcer if any of your relatives have them. Men get twice as many duodenal ulcers, while the rate of gastric ulcers is about the same in both sexes. Smoking–even chewing nicotine gum–certainly does cause ulcers. In fact, smoking not only doubles your risk of coming down with an ulcer but slows its healing and contributes to recurrence. If you quit smoking and take no medication at all, your ulcer will heal more quickly than if you down drugs conscientiously but continue to smoke. Another sure cause of ulcers is regular use of aspirin and other nonsteroidal anti- inflammatory medications such as Motrin or Advil. Arthritis patients are particularly apt to take these drugs habitually over a long period of time. But aspirin and similar medications inhibit your stomach’s production of prostaglandins, which are the key substances for cytoprotection. Prostaglandins govern mucus secretion and other mechanisms that protect your stomach’s mucosal lining from injury by gastric juice, as well as other chemicals. If you stop taking the offending medications, your ulcers usually clear up. Cherry angioma | Derm. Net New Zealand. Home ». Topics A–Z » Cherry angioma. Author: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, December 2. What is an angioma? Angioma or haemangioma (American spelling ‘hemangioma’) describes a benign overgrowth of cutaneous venules. Angioma is due to proliferating endothelial cells; these are the cells that line the inside of a blood vessel. Angiomas can arise in early life (infantile proliferative haemangioma) or later in life. What is a cherry angioma? A cherry angioma is a small papular angioma arising in adult life. See more images of cherry angioma .. Who gets cherry angioma? Cherry angiomas are very common in males and females of any age or race. They are more noticeable in white skin than in skin of colour. They markedly increase in number from about the age of 4. There may be a family history of similar lesions. Eruptive cherry angiomas have been rarely reported to be associated with an internal malignancy. What is the cause of cherry angioma? Their cause is unknown. What are the clinical features of cherry angioma? Cherry angioma is a firm red, blue or purple papule, 0. When thrombosed, they can appear black in colour until evaluated with a dermatoscope when the red or purple colour is more easily seen. Cherry angioma may develop on any part of the body but most often appear on the scalp, face, lips and trunk. Cherry angiomas are also known as Campbell de Morgan spots. What is the differential diagnosis for cherry angioma? Cherry angioma is usually easy to diagnose, but occasionally it may be confused with: Spider telangiectasis, also known as spider naevus, is sometimes (incorrectly) called a spider angioma but this is a vascular dilatation and not a proliferation of endothelial cells. What investigations should be done for angioma? Cherry angioma is usually diagnosed clinically and no investigations are necessary for the majority of lesions. It has a characteristic red- clod or lobular pattern on dermatoscopy (called lacunar pattern using conventional pattern analysis). When there is uncertainty about the diagnosis, a biopsy may be performed. The angioma is composed of venules in a thickened papillary dermis. Collagen bundles may be prominent between the lobules. Treatment of cherry angioma. Cherry angiomas are harmless, so do not have to be treated. Occasionally, they are removed to exclude a malignant skin lesion such as nodular melanoma. If desired for cosmetic reasons, a cherry angioma can be simply removed by one of the following methods: Related information. Bile | Define Bile at Dictionary. French bile (1. 7c.) "bile," also, informally, "anger," from Latin bilis "fluid secreted by the liver," also one of the four humors (also known as choler), thus "anger, peevishness" (especially as black bile, 1. ![]() 分類 膠質瘤. 最常見的腦瘤是膠質瘤(glioma),其源自膠細胞,而膠細胞是腦組織中的支持性組織。其分類為 : 星形細胞瘤.Background Ewing's sarcoma and primitive neuroectodermal tumor of bone are closely related, highly malignant tumors of children, adolescents, and young adults. A new. Brain tumors are a diverse group of neoplasms arising from different cells within the central nervous system (CNS) or from systemic tumors that have metastasized to. AJR:200, May 2013 W485 MRI of Pediatric Supratentorial Tumors behavior, and genetic characterization. This group of tumors includes diffuse astrocytoma. Accurate, up-to-date, comprehensive cancer information from the U.S. government's principal agency for cancer research. Grier HE. The Ewing family of tumors. Ewing's sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 1997; 44:991. Ambros IM, Ambros PF, Strehl S, et al. World Health Organization (WHO) Updates Official Classification of Tumors of the Central Nervous System. On May 9, 2016, the World Health Organization (WHO) published. NERVOUS SYSTEM DISEASE Ed Friedlander, M.D., Pathologist [email protected] No texting or chat messages, please. Ordinary e-mails are welcome. A glioma is a type of tumor that starts in the glial cells of the brain or the spine. Gliomas comprise about 30 per cent of all brain tumors and central nervous. An Error Occurred Setting Your User Cookie. This site uses cookies to improve performance. If your browser does not accept cookies, you cannot view this site. Setting Your Browser to Accept Cookies. There are many reasons why a cookie could not be set correctly. Below are the most common reasons: You have cookies disabled in your browser. You need to reset your browser to accept cookies or to ask you if you want to accept cookies. 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In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site. Allowing a website to create a cookie does not give that or any other site access to the. Brain Cancer 或 Brain Tumour)是指腦內異常細胞的形成[2],定義為任何顱內腫瘤,發生的位置包括了腦本身各種細胞(神經元、膠質細胞、淋巴組織以及血管)、腦神經(許旺氏細胞)、腦膜、頭骨、腦下垂體以及由其它器官轉移的轉移性腦瘤[7]。主要分成兩種:惡性或癌症腫瘤,以及良性腫瘤[2]。癌症腫瘤可再分為原發性腦瘤與轉移性腦瘤[1]。所有型態的腦瘤都會產生症狀,因為腦瘤漸漸增大必會壓住該處之神經,影響其功能,所以臨床表現因部位不同[2],包含頭痛、抽搐、視力問題、嘔吐、意識改變[1]。典型的頭痛為早晨時惡化,並伴隨嘔吐而頭痛減緩[2]。其他特殊的症狀包含行走、說話困難,以及感覺異常[1][3]。當疾病進展時,可能發生失去意識[3]。在惡性腦瘤晚期,腫瘤細胞也會轉移至身體其他臟器。大部分腦瘤的發生原因不明[2]。某些危險因子可能牽涉其中,包括一些基因症候群如神經纖維瘤病(神經纖維瘤症後群),以及暴露於化學物質(如氯乙烯)、人類皰疹病毒第四型(Epstein- Barr virus)或游離輻射[2][1][3]。而對於手機使用產生的相關疑慮,目前缺乏明確證據[3]。在成人病患中最常見的原發性腦瘤是腦膜瘤和星狀細胞瘤,後者如神經膠母細胞瘤(glioblastoma)[1];而在兒童病患中最常見的則是髓母細胞瘤(medulloblastoma)[3]。腦瘤的診斷以身體診察搭配電腦斷層掃描(computed tomography)或磁共振影像(magnetic resonance imaging)為主[2],之後會進行切片檢查確認[1],再根據病理結果區分為不同等級或嚴重度[1]。治療方式可能綜合包括手術、放射線療法和化學療法數種方式[1]。若有抽搐情形可使用抗癲癇藥物[1]。Dexamethasone 與Furosemide[註 1][1]。部分腫瘤成長較緩慢,僅需要長期追蹤[1]。以病患的免疫系統作為治療方式,目前仍然在研究中[2]。預後則依腫瘤型態而定[3]。神經膠細胞瘤通常預後較差,而腦膜瘤較好[3]。在美國,腦瘤平均五年存活率為3. Astrocytoma):是最常見的膠質瘤,占膠質瘤的7. Pilocytic Astrocytoma),第二級- 星狀細胞瘤(Astrocytoma)屬低惡性腫瘤,第三級- 分化不良星狀細胞瘤(Anaplastic Astrocytoma;AA),第四級- 多型性神經膠母細胞瘤(Glioblastoma Multiform;GBM)屬惡性腫瘤。寡樹突膠質瘤(Oligodendroglioma)室管膜瘤(Ependymoma)非膠質瘤[編輯]其它的非膠質腦瘤,常見的有下列幾種:胚芽腫瘤(Embryonal Tumor):屬惡性腫瘤,依部位及分化程度可分為成神經管細胞瘤、室管膜母細胞瘤(Ependymoblastoma)、原始性神經外胚層腫瘤(Primitive Neuroectodermal Tumor;PNET)以及非典型性畸胎樣橫紋肌肉瘤(Atypical Rhabdoid/Terotoid Tumor;AT/RT)腦膜瘤(Meningioma)顱咽管瘤(Craniopharyngioma)神經鞘瘤(Schwannoma)神經節膠質細胞瘤(Ganglioglioma)腦下垂體腫瘤(Pituitary Adenoma)脈絡叢腫瘤(Choroid Plexus Tumor)腦腫瘤的症狀主要取決於兩個因素:腫瘤的大小(體積),腫瘤的位置。而症狀出現的時間點和病程通常和腫瘤的性質有關(良性-慢速增長/晚期症狀出現,或惡性-快速增長/早期症狀出現)。大型腦腫瘤或腫瘤腫脹伴隨的腦水腫會導致顱內壓升高,在臨床上會造成頭痛、嘔吐、意識狀態改變(嗜睡、昏迷)亦或是瞳孔病變。此外,即便是小型腫瘤,也都可能阻礙腦脊液(CSF)的通過而導致早期顱內壓的增加。在幼兒,顱內壓的增加也可能導致頭骨直徑增加和囟門鼓脹。根據腦腫瘤的位置,無論是經由壓迫或滲透轉移,都有可能會直接損害腫瘤生長部位以及附近的腦結構,導致局部神經症狀的發生,例如認知和行為能力的下降、個性變化、偏癱、感覺遲鈍、失語症、視野變小以及顏部癱瘓等[1. Pub. Med也有相關報導指出膠質母細胞瘤、間變性星形細胞瘤,和genetic acute hepatic porphyrias(PCT、AIP、HCP和VP)有關。影像診斷在腦腫瘤的判讀上是相當重要的。影像檢查:除了臨床症狀的判斷,隨著科學的進步,影像檢查可快速並增加腦瘤診斷的準確性,對於術後追蹤治療也相當有幫助。目前影像檢查包括有:電腦斷層掃瞄(Computed Tomography;CT)、磁共振成像(Magnetic Resonance Imaging;MRI)、腦波圖(Electroncephalography;EEG)以及腦血管攝影。切片檢查:雖然影像檢查的進步,醫師常常可以藉由影像檢查來做腦病變的診斷,但有些情形更需要做切片檢查以確定病理診斷,尤其在腦瘤經評估是無法開刀切除時,切片手術有助於後續治療,目前切片檢查包括了立體定位切片檢查以及開顱切片檢查[1. ALA)標定癌細胞,使其顯現螢光,能夠幫助腫瘤切除率的提升,現已有產品Gliolan(medac Gmb. H)在歐洲取得核准上市。而針對一些較深層的腫瘤或無法以傳統開刀手術移除的腫瘤,立體定向放射手術(Gamma knife、Cyberknife or Novalis Tx radiosurgery)也是另一種手術的選擇。對於良性腫瘤,採用手術完全切除的機率較高,病人的存活率也較高,如大腦或小腦星狀細胞瘤、蝶鞍顱咽管瘤、腦室脈絡叢瘤等,不需進行放射線或化學藥物治療,復發機率低,但需定期做CT或MRI復檢。未能以手術全部切除的殘餘的良性瘤可視情況予以觀察追蹤、或隨即使用化學藥物治療,或放射線治療。對於一般的惡性腦瘤,如退行性星狀細胞瘤、髓母細胞瘤、腦室膜瘤、畸胎瘤等,能夠完全切除或接近完全切除者,預後較佳,但必需加上放射治療及或化學藥物治療,方能達到控制腫瘤生長的目的。初發性腦瘤病人的存活率與腫瘤的類型及病人的年齡和生理機能有相當大的關聯性,這些因素將會影響病人選擇治療的模式[1. BBB)的特殊結構,腦瘤的化學治療仍受到許多限制,任何化療藥物只能通過藥物的脂溶性通過血管內膜細胞,進而進入腫瘤細胞產生作用,這樣的模式影響了藥物作用的速度與效率[1. BCNU和CCNU,或者用PVC方案(甲基苄肼+長春新鹼+CCNU),有一定療效,但有延遲和累積骨髓抑制和肺毒性等副作用,易產生耐藥性。在新型治療腦瘤的化療藥物研發方面,目前有了新的進展。一種是口服藥物「Temozolomide」,另一則是於手術時直接植入的藥物晶片「Gliadel(BCNU) 」。Temozolomide(替莫唑胺)(schering- plough)Temozolomide是一個具有抗腫瘤活性,含有咪唑四嗪(imidazotetrazine)環的烷化劑類抗腫瘤藥物。它本身並沒有活性,屬於前體藥物,須在生理水平PH下經非酶途徑轉化為活性化合物MITC(5- (3- 甲基三氮烯- 1- 基)咪唑- 4- 醯胺),後者再進一步水解成活性代謝物方能顯現抗腫瘤活性。理論上,MTIC的抗腫瘤活性主要是通過與鳥嘌呤的第六位氧原子產生主要的烷基化作用,同時也會與鳥嘌呤的第七位氮原子發生次要的附加性烷基化作用,因此隨後發生的細胞毒性被認為是與這些異常修復的甲基化合物有關。Temozolomide採用口服給藥的方式,可採用放射治療同步進行輔助性治療,可用於治療新診斷的多形性神經膠母細胞瘤或復發性惡性神經膠質瘤,在治療過程中需嚴密監測化療過程中嗜中性白血球以及血小板的數量,避免發生血液毒性的副作用。美國FDA於1. Guilford公司開發,以BCNU為活性成分,聚苯丙生2. Gliadel,治療復發性惡性腦瘤的申請,可在手術後,將藥物直接放置於復發性惡性膠質細胞瘤之腦組織中,讓藥物緩慢釋放,進行持續性化學治療。經過多年多中心臨床試驗,FDA於2. Gliadel用於原發性惡性腦瘤的治療,據文獻報導,Gliadel可延長原發性及復發性惡性腦瘤患者的中間存活期。該治療方法的獨特之處在於其給藥方式及釋放系統。在外科手術過程中,先將腫瘤組織切除,留下一個小空腔,然後植入這種定期釋放的晶片。這些晶片會在2~3周之內慢慢地分解、融化,釋放出的藥物可直接進入腫瘤區,殺死那些在外科手術中沒有切除乾淨的腫瘤細胞,並且能在不損害其它組織的情況下使病變局部能達到有效的血藥濃度,延緩了疾病的進展。美國癌症中心聯盟(National Comprehensive Cancer Network,NCCN)針對惡性腦瘤的最新治療原則中指出,原發及復發惡性腦瘤患者皆可予以手術切除腫瘤時同時置入Gliadel(BCNU),術後輔以放射線治療或Temozolomide等化療藥物治療,據文獻報導,採用此治療模式可有效延長患者的存活中位數[2. The cancer also bad for a man's brain!放射線治療[編輯]放射線治療是利用放射線或者γ射線、高速中子射線對腫瘤細胞進行殺滅,簡稱放療。放射線治療是最常見的腫瘤輔助治療手段,一般於手術後1至2星期開始。放射線治療主要利用腫瘤細胞對放射線比較敏感,容易受到放射線的傷害來殺死腫瘤細胞,一般治療約需四至八個星期,會依據不同的腫瘤病理診斷、分化程度及影像醫學檢查結果而決定照射範圍的大小及劑量。對許多惡性腫瘤及無法安全切除的深部位良性瘤,放射線治療是一種有效的方法。目前放射線治療己發展至隨形或定位方式,包括直線加速器的放射治療、伽傌射線定位放射手術、光子刀等。但部分惡性腦瘤仍需進行大範圍腦部放射線治療或全顱及脊椎放射治療。2. Texas出版,Anderson Cancer Center研究指出病人接受立體定向放射外科手術(stereotactic radiosurgery;SRS)和全腦放射治療(whole brain radiation therapy;WBRT)對於病人學習和記憶的損傷有較大的副作用和風險性[2. DC- CIK生物免疫治療[編輯]DC- CIK生物免疫療法是以回輸DC細胞(樹狀細胞)、CIK細胞(細胞因子誘導的殺傷細胞)為主的免疫治療,通過專門的血液分離機採集患者自身體內抗癌細胞送至GMP潔淨實驗室進行體外培養,增強病人免疫細胞數量和功能。獲取成熟的、具有識別腫瘤能力的DC細胞和數量增值1. CIK細胞後,將兩種細胞以輸液的方式回輸至患者體內,對腫瘤細胞回輸至患者體內,對腫瘤細胞進行徹底、精準的殺傷。在美國經過多年臨床研究,相關臨床試驗基本全部宣告失敗,DC- CIK免疫療法沒有在大規模臨床實驗中有統計意義上的顯著療效,因此DC- CIK療法在美國沒有得到上市許可,在美國已經鮮有DC- CIK用於癌症治療的臨床試驗。盛行率[編輯]死於腦癌的名人[編輯]中華民國(台灣)[編輯]參考文獻[編輯]^ 1. Adult Brain Tumors Treatment. NCI. 2. 01. 4- 0. June 2. 01. 4]. ^ 2. General Information About Adult Brain Tumors. NCI. 2. 01. 4- 0. June 2. 01. 4]. ^ 3. World Cancer Report 2. World Health Organization. Chapter 5. 1. 6. ISBN 9. SEER Stat Fact Sheets: Brain and Other Nervous System Cance. NCI. [1. 8 June 2. July 2. 01. 4). ^GBD 2. Disease and Injury Incidence and Prevalence, Collaborators. Wall of Memory [ARCHIVED] | Cancer Kids. Please note that this is an archived version of the Cancer Kids Wall of Memory. No further effort will be made to update this page. Some of these links may not work. David Edward Lowe. March 1. 5, 1. 97. November 0. 2, 1. Neuroblastoma. Lawrence Michael Mc. Reynolds. May 1. 2, 1. August 1. 7, 1. 97. Medulla Blastoma. You were such a beautiful baby boy. I loved you dearly. I often wonder what you would look like today. You were so smart,funny, lovable, strong and determined. I have never forgotten you, and look forward to the day that we will meet again. Kathy Lynn Atkinson. March 1. 7, 1. 96. October 1. 3, 1. 97. Ewing’s Sarcoma. Christopher Timothy Claffey. June 0. 2, 1. 96. August 0. 8, 1. 97. Burkitt’s Lymphoma. My brave and loving brother. I share your legacy with my children. I will remember and love you always. You will always be my motivation and inspiration. We will hug you in heaven. Robert Kieswetter. January 0. 9, 1. 97. August 1. 7, 1. 97. Leukemia. Ricky Alexander Tilly. July 0. 7, 1. 97. October 1. 5, 1. 97. Neuroblastoma. Jamie Shomo. July 1. 5, 1. 96. August 1. 0, 1. 97. Leukemia. A wonderful friend who I think of often and still miss greatly…love you Jamie. Robert Patrick Parke. August 1. 5, 1. 97. March 3. 1, 1. 98. Ependymoblastoma. Amber Marie Calistro. February 2. 8, 1. October 3. 0, 1. 98. Rhabdomyosarcoma. Amber knew why she was sent to earth. A few days before she died, she called me to her side and told me, “Mom, I KNOW I’m here to help a lot of people.” Although she said many wise and wonderful things in her 4 1/2 years, I was astounded. From the moment she was born, I knew I was “chosen” to be Amber’s mother but the reason why was unclear. I documented our life together and especially her journey through cancer with recordings, movies, photos, media coverage, her drawings, and a journal. It helped me cope, gave me purpose, and ensured that her life and death would have meaning, even after she died. Having found Bernie Siegel to care for her, I was blessed beyond words. He helped us help her “cross the threshold” between life and death. Her death was miraculous. The moment she stopped breathing, I physically felt God… the Higher Power… the world that we cannot see with our eyes. Amber died on my 2. Before she died, she gave me the most precious gift I’ve ever received: The secret to what happens after our body dies. Mom, when I die, I’ll still be Amber, I’ll just be DIFFERENT.” Knowing that, I did not “lose a child,” she did not “pass away.” She simply changed. She is with me now, but different. For most of the 3. I dug deep to call up the feelings and emotions I needed to write “Embrace the Angel.” It is now published and I am ready to, once again, reach out and spread Amber’s message of “hope, heaven, and the miracle of life and death.”But there is one thing holding me back. It is not her death, it is cancer. It is not the fact that she was “killed,” is the the “murderer.” I am trying to “wrap myself around” this horrible disease that kills so many of our loved ones. I must find peace and understanding while working to bring people together, raise awareness, and facilitate change in the “Cancer World.” But how? Perhaps returning to the moment in time when my “Life Task” is the answer. After she died at home, we took her body to St. Raphael’s Hospital in New Haven, CT. Bernie called ahead to make the arrangements. Excerpt from Chapter 1. Crossing the Threshold: “I walked towards the automatic doors, her lifeless body swaying to my step. Beyond the parting doors, I could see a crowd. Nurses, doctors, secretaries, visitors, priests, and nuns had gathered there to pay their last respects to this little girltheir little girlwho had fought so bravely to the very end. At once, I could see I wasn’t alone, that they had suffered, too. They had hoped for her recovery, prayed for her life, and watched along with me as she slowly and painfully died. Many were crying. Their grief forced them to turn to each other for comfort. I felt no pangs of sadness or sorrow; I still felt the glory of God. I was at peace, and so was my baby. Dr. Raine, a young intern, directed us to a small room that was separated from the Emergency Room by a curtain. I placed her body on the stretcher and studied it… absorbing every inch… filling my mind with the memory of Amber. Perfect feet… hands… lips… eyes…” I stopped at the tumor. I moved closer to inspect it. Since she wasn’t there and could feel no pain, I shook it. It felt like gelatin: Soft, powerless, sickening. It was enormous; nearly the same size as her head. How can something so pathetic… so ugly… kill my beautiful little girl?!?!” Just under my skin, seething rage was coursing through my veins. In my mind, I could see a battlefield strewn with the bodies of all the other children who had died before Amber and the bodies of children yet to come. Instantly, I felt as though I’d been injected with a tranquilizer. My hatred gave way to a new understanding. Don’t waste your life hating. Welcome to City of Logan, Utah. ECONOMICDevelopment. Logan City is a vibrant, growing university community with a conscientious and highly- educated workforce. The City Administration is eager to collaborate with compatible businesses who would like to locate in Logan. Visit our Economic Development page to see what Logan has to offer or contact Kirk Jensen, Economic Development Director at (4. The Line Creek Loudmouth This blog features observations from Line Creek Valley resident Wes Minder. The comments on the blog do not represent the views of the City. On-time delivery The project will be delivered by your deadline. Should we have difficulty meeting your specified deadline, we will contact you prior to the deadline. The global leader in innovative language translation services, interpreting, localization, plus testing and training. Learn how we bridge language barriers. Phone chat line is a great way of meeting new people for fun, dating, or friendship. It can be considered as a dating services, but unlike online dating, instead of. Workplace Options is a leading provider of global employee support, work-life, and wellness services with Service Centers and locations worldwide. Connecticut Common Thread Warmline 800-316-9145 5 pm – 10 pm, 7 days a week Greater Waterbury Peer Support Line 800-314-2680 5 pm – 10 pm, 7 days a week including. The official website of Logan City, providing general information, links to city departments, local services, calendar, and contact information. ![]() Online Services. Order replacement parts for Montana private and public use airports. Enter air emissions for your permitted/registered facility. Apply yourself or nominate someone for appointment to a board, council, or commission. Schedule an appointment for driver licensing services at an exam station. Apply for, or renew, your Asbestos Accreditation. 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Five for Fighting - Five For Fighting arrived on the scene in 1997 as John Ondrasik, who is the core & steady member of what's pretty much a one-man band. 3 Women Entrepreneurs Who Made Their Own Rules For centuries, women were considered homemakers. Now, they are taking over the business world. Very Funny Pics | Funny Pictures, Memes, Cartoons and Quotes. Fun Cat Pictures. The Funniest Pictures. Funny Pictures and Quotes. Song of Myself. Won't you help support Day. Poems? 1. 81. 9- 1. I celebrate myself, and sing myself. And what I assume you shall assume. For every atom belonging to me as good belongs to you. I loafe and invite my soul. I lean and loafe at my ease observing a spear of summer grass. My tongue, every atom of my blood, form'd from this soil, this air. Born here of parents born here from parents the same, and their. I, now thirty- seven years old in perfect health begin. Hoping to cease not till death. Creeds and schools in abeyance. Retiring back a while sufficed at what they are, but never forgotten. I harbor for good or bad, I permit to speak at every hazard. Nature without check with original energy. Houses and rooms are full of perfumes, the shelves are crowded with. I breathe the fragrance myself and know it and like it. The distillation would intoxicate me also, but I shall not let it. The atmosphere is not a perfume, it has no taste of the. It is for my mouth forever, I am in love with it. I will go to the bank by the wood and become undisguised and naked. I am mad for it to be in contact with me. ![]() The smoke of my own breath. Echoes, ripples, buzz'd whispers, love- root, silk- thread, crotch and vine. My respiration and inspiration, the beating of my heart, the passing. The sniff of green leaves and dry leaves, and of the shore and. The sound of the belch'd words of my voice loos'd to the eddies of. A few light kisses, a few embraces, a reaching around of arms. The play of shine and shade on the trees as the supple boughs wag. The delight alone or in the rush of the streets, or along the fields. The feeling of health, the full- noon trill, the song of me rising. Have you reckon'd a thousand acres much? Have you practis'd so long to learn to read? Have you felt so proud to get at the meaning of poems? Stop this day and night with me and you shall possess the origin of. You shall possess the good of the earth and sun, (there are millions. You shall no longer take things at second or third hand, nor look through. You shall not look through my eyes either, nor take things from me. You shall listen to all sides and filter them from your self. I have heard what the talkers were talking, the talk of the. But I do not talk of the beginning or the end. There was never any more inception than there is now. Nor any more youth or age than there is now. And will never be any more perfection than there is now. Nor any more heaven or hell than there is now. Urge and urge and urge. Always the procreant urge of the world. Out of the dimness opposite equals advance, always substance and. Always a knit of identity, always distinction, always a breed of life. To elaborate is no avail, learn'd and unlearn'd feel that it is so. Sure as the most certain sure, plumb in the uprights, well. Stout as a horse, affectionate, haughty, electrical. I and this mystery here we stand. Clear and sweet is my soul, and clear and sweet is all that is not my soul. Lack one lacks both, and the unseen is proved by the seen. Till that becomes unseen and receives proof in its turn. Showing the best and dividing it from the worst age vexes age. Knowing the perfect fitness and equanimity of things, while they. I am silent, and go bathe and admire myself. Welcome is every organ and attribute of me, and of any man hearty and clean. Not an inch nor a particle of an inch is vile, and none shall be. I am satisfied- -I see, dance, laugh, sing. As the hugging and loving bed- fellow sleeps at my side through the night. Leaving me baskets cover'd with white towels swelling the house with. Shall I postpone my acceptation and realization and scream at my eyes. That they turn from gazing after and down the road. And forthwith cipher and show me to a cent. Exactly the value of one and exactly the value of two, and which is ahead? Trippers and askers surround me. People I meet, the effect upon me of my early life or the ward and. I live in, or the nation. The latest dates, discoveries, inventions, societies, authors old and new. My dinner, dress, associates, looks, compliments, dues. The real or fancied indifference of some man or woman I love. The sickness of one of my folks or of myself, or ill- doing or loss. Battles, the horrors of fratricidal war, the fever of doubtful news. These come to me days and nights and go from me again. But they are not the Me myself. Apart from the pulling and hauling stands what I am. Stands amused, complacent, compassionating, idle, unitary. Looks down, is erect, or bends an arm on an impalpable certain rest. Looking with side- curved head curious what will come next. Both in and out of the game and watching and wondering at it. Backward I see in my own days where I sweated through fog with. I have no mockings or arguments, I witness and wait. I believe in you my soul, the other I am must not abase itself to you. And you must not be abased to the other. Loafe with me on the grass, loose the stop from your throat. Not words, not music or rhyme I want, not custom or lecture, not. ![]() These party games work well for adults. Click on a game title to read the details of how to prepare and play the party game. Puzzled by what to give the gamer on your list? The solution is easy! Just browse our selection of fun games for kids and adults. Check out the list of 10 team building games and activities especially designed to improve employee planning skills and building trust within a team. Dinner Party Games and activities for dinner, wine tastings, game nights and social gatherings among friends. Dinner Party Games. Whether you are having a Christmas party with family and friends or an office party with co-workers, here's a list of games that will add some fun to your celebration. Huge list of fun teenage party games! Coolest, sickest games for every kind of teen party - Everything you need to take the BORE factor out of your party! Birthday Party Games for Kids. It is easy to make sure your child has the very best birthday by including some birthday party games for kids to make it special and fun. A list of Halloween party games for adults only that will be a hit at your next Halloween party. These include ideas for small and large parties. Tons of FUN bible party games and church party games to play with your church group or christian friends. Party games are a great way to bring people together, break the ice or just provide old friends with new tricks. From easy, no-frills fun to entertaining electronics.Kid's Birthday Party Games, Fun Games and Activities. Take an ordinary ping pong table and turn it into a battleground involving lots of hot air, focus and unexpected action as teams work to score points on the other team, without a paddle! Fun for kids, teens and adults. Game details, instructions and variations. Party Games for Adults Archives. Use your body in a team- based Rock, paper, scissors game! Brain Puzzles, Fun Games for Kids and Adults. Free Bible Games for Active Fun. In search of free bible games? Well you’ve arrived at a great resource for fun games that are biblically based! Who says bible activities have to be a matter of question and answer? Sometimes its just a matter of having fun. Here you’ll find some really awesome and free bible games that will be a hit at your next religious outdoor event or rec- room fun. These fun games are great children bible games as well as awesome fun for adults. Bible activities can be so much more than a drill of questions and here you’ll find some great active alternatives. So let a fresh wind of free bible games blow through your next event and get everybody filled with joy and laughter. Don’t forget to check out the other bible games categories as there are more free bible games to be found there. Because the games on this site have a one game fits all approach, the other free bible games provided may very well make a great addition to what you’ve already found. Be blessed and have fun with these free bible games. My Sheep Know My Voice. Start your free bible games with this y Voiceexcellent pick. This fun game calls for no memory verses or bible stories. It’s a game of faith, trust and a listening ear. A simple game with a biblical theme that everyone can enjoy. This is certainly one of the free bible games you’ll want to play again and again! What You’ll Need: 3 large containers or buckets, 2 blind folds, ball pit balls, stakes & twine (outdoors) or painters tape (indoors). How to Play: Step 1: Mark out a large rectangular perimeter (at least 1. X 1. 2). If outdoors, use stakes & twine. If indoors, then painters tape is a great option. Take one of the three buckets, fill it with the ball pit balls and place it on the ground in the center of the rectangle. Place the other two empty buckets on opposite ends of the rectangle. The empty buckets on the opposite ends will act as point buckets for each team. Step 2: Create two teams with at least 3 people per team. Assign each team a color that corresponds to one of the ball colors as that will be their target color. Ensure that there is an equal amount of balls of each team’s assigned color. Step 3: Select one member from each team, blind fold them then place them on opposite ends of the center bucket of balls (they are the sheep). The two team members that are blind folded are the only ones permitted within the perimeter during a round. Everyone else, including the other team members, must remain outside the perimeter. Step 4: Without making the team members who are blind folded aware of who you’re selecting; select 2 individuals (onlookers – not from the teams) instructing them to remain silent. These individuals will act as the sheppards who’s voice the blind folded sheep must recognize. Of the 2 sheppards selected, during round one, one will act as sheppard for team 1 while the other will act as sheppard for team 2. Sheppards too must remain outside the rectangular perimeter. Step 5: Inform the sheep (those who are blind folded) that they will have 6. Now, because the sheep cannot see they must know and listen to the voice of their sheppard in order to be successful. If a ball falls from the hands of any of the sheep during a round it may be retrieved under the instruction of their sheppard and placed into their point bucket. However, if the ball drops and rolls outside of the perimeter it is disqualified for that round. Step 6: Once the sheep have been given their objective, one at a time, instruct the sheppards for each team to say “I am your sheppard!” This must be said loud and clear for the sheep to hear. Once they have heard the voice of their sheppard it is up to them to remember that voice as that will be their only guide to winning the race. Step 7: At the sound of the “go” signal, the sheep will attempt to quickly grab as many balls as possible that correspond with their team’s color and transfer them to their team’s point bucket. The sheppard for each team must verbally inform the sheep if they’re picking up the wrong ball color, guide them to their point bucket, guide them back to the center bucket, keep them from banging heads with the other sheep, etc. The team with the most balls of the correct color in their bucket at the end of 6. Step 8: Begin a new round by rotating to the next team member on each team until all team members have had a turn to act as sheep. Select a new sheppard for each round and for each team so the sheppard remains unknown and identifiable only by his or her voice. The team that has placed the highest number of the correct colored balls in their bucket at the end of all 3 rounds wins the game! There’s no way you’re going to forget to include this in your list of free bible games for your next gathering. Note: Encourage onlookers to cheer (cheer – not instruct) for whichever team they fancy. This makes the game all the more exciting for the onlookers. Russian dating agencies. 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The more. successful the agency is, the more letters its girls receive. The more. letters the girls receive, the more eager they are in recommending the. The more eager they are in recommending the. The. more profiles the agency has, the more men join it. The more men join. Bingo. On the downside of. A lady featured by a well established. A WEEK, especially if she has an. The agency usually indicates if a woman has access to. But addresses and. They. provide permanent cash flow but seldom are the main source of income. The serious money is made on tours. Either it's a group romantic tour. Gift delivery. translation and email forwarding services offered by a Western based. Most of the agencies have a representative in one of. Russian cities who prints and mails forwarded letters, and if the. The best in this case is if the representative is. Moscow; letters from Moscow arrive considerably fast (3- 7. The strong point of. Western agencies is their large databases, but it turns out to be their. That's why applying to women who have. In the case of Western. Thus you will be. Russian marriage agencies. In Russian there is no. Local agencies cannot. Some agencies will let you contact women free of charge. Local agencies also. Russian. As they are situated. Russian, and are physically available for. Competition on the. The others. stick to one agency, make friends with agencies' personnel and their. The majority disappears after. They try to contact men from the catalogues offered by the. If later the agency phones asking them to fetch their. If the agency doesn't phone, they will never come themselves. Most of the ladies do. The majority of local. The agency. sends/rents/sells women's data to western agencies (in a case if it's. The. agencies that are in between will have a website with one of the free. Xoom or Hypermart. Local agencies usually. Ladies usually pay a fee. Women also pay for sending/receiving emails and. When. choosing between sending a letter to overseas' pen friend or buying a. Russian females usually prefer the latter. Their fees usually cannot be relied on to cover the agencies. Internet connection and. So the main source of income for local agencies has to be. Some. agencies offer free listing for women under 3. Sending a letter will. Local agencies make. They also offer individual tours for men but rarely have. When a reseller asked one of the agencies that offered a. A good local agency may. It pretty much. depends on the personality of its owner but you never know. Local agencies depend on. If a lady received a letter, she is asked to. In more. prominent cases the agency can use a woman's data to attract clients. Even if a couple is. Many experienced agencies do not allow any money matter. The agency will try to convince a lady that she. The lady in her. letters will ask her boyfriend to trust the agency, and do what they. If he tries to do something in a different way, he starts. If he does not trust her, they should stop any. He made her cry. She could not sleep the whole night. He. broke her heart.. So the man has to follow. I have heard about cases when men were asked to pay 2- 3. BEFORE they actually. The less experienced is. Nevertheless. restricting clients' freedom gives its results, and experienced. They provide "better". On the other. hand, they can advise a woman against a particular candidate, and after. Also, I have heard about cases when men sent money and. To avoid heartbreak when. THE VERY FIRST LETTER. If she does not have a phone, ask her. If her English. is not good enough, you can use option of conference calls offered by. You need a way of direct contact in case if you face. Give your postal address, and ask a lady to. Try to teach your lady to use email on her. English. But if she struggles a lot. Contact the agency's. Never hesitate to ask a question if necessary. 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In addition to all the great features you also will have more privacy and security than most other online personals. Your profile will not appear in search engines and your data will not be sold or offered to any 3rd party companies or organizations for solicitation. Home |. Contact Us | About TGD |. Advertise | TOS |. Privacy | HELP. Number Days Sim Date - Pacthesis Games. Main menu will appear after game loads. If screen appears white- please wait. Stuck? Need help? Click here for the walkthrough. Number Days Sim Date is a cute dating simulation for girls! Play online for free now on Pacthesis Games - official home to romantic dating games. It's the grand opening day of the new amusement park in town, but trouble rises when you find yourself trapped inside along with a cast of intriguing characters. Find a way out, find the truth, and find your way into the hearts of others. This story has 8 different endings. Hide this message X. 193. Community Content by ScribbleLive. Play Crush Crush, a free online game on Kongregate. What does this mean for me? You will always be able to play your favorite games on Kongregate. However, certain site features may suddenly stop working and leave you with a severely degraded experience. What should I do? We strongly urge all our users to upgrade to modern browsers for a better experience and improved security. ![]() Play dating sims inspired by anime, visual novels and otome games. Play online for free on Pacthesis Games — official home to the Days Sim Date series. Relationships Forum - Dating, marriage - City-Data. AskMen's Dating channel offers you all the advice you need to become a Better Man in romance and relationships. 19 too young online dating My own dating site. Christmas; Polish; Audition; Lollipop; Close Up; Pretty; Posing; Austria Housewife; Scandal. We suggest you install the latest version of one of these browsers: No Thanks. Browsing Anime. Browse the newest, top selling and discounted Anime products on Steam 東方憑依華 ~ Antinomy of Common Flowers.樱之杜†净梦者 1 第一部 Sakura no Mori † Dreamers part. Time Tenshi Paradox: Episode 1. Showing 1- 1. 5 of 9. SWORD ART ONLINE: Fatal Bullet東方憑依華 ~ Antinomy of Common Flowers. Sword Art Online: Hollow Realization Deluxe Edition. Marvel vs. Capcom: Infinite. Marvel vs. Capcom: Infinite - Deluxe Edition. Ys VIII: Lacrimosa of DANA / イースVIII- Lacrimosa of DANA- FINAL FANTASY XIV Online Complete Edition (PAL). Showing 1- 1. 5 of 8. FINAL FANTASY XIV Online Starter Edition. Doki Doki Literature Club! Tree of Savior (English Ver.). Showing 1- 1. 5 of 9. Sorcery Jokers All Ages Version. Shalnor Legends: Sacred Lands. Cassandra's Fabulous Foray. What!? My Neighbors Are Demons!!? Showing 1- 1. 5 of 4. Otome game - Wikipedia"Otome" redirects here. For the anime series, see My- Otome. An otome game(乙女ゲーム,otome gēmu, literally "maiden game") is a story- based video game that is targeted towards women. Generally one of the goals, besides the main plot goal, is to develop a romantic relationship between the female player character and one of several male or female characters. This genre is most established in Japan, and is mostly made up of visual novels and simulation games; particularly dating sims and life simulation games. History[edit]The first otome game is generally acknowledged to be Angelique, released in 1. Koei in Japan for the Super Famicom, and created by an all- woman team.[1] The game was originally targeted to pre- teen and younger teenage girls, but became unexpectedly popular with older teenagers and women in their 2. Angelique is credited with "set[ting] up the specifics and conventions of women’s games: a focus on romance, easy controls and utilizing other multimedia."[1] In 2. Konami released its very successful Tokimeki Memorial Girl's Side, which brought many new fans to the still- new genre. In 2. 00. 6, Famitsu's listings for the Top 2. Early games borrowed heavily from the iconography and story conventions of "retro shoujo manga", "the archetypical girly heroines, the emphasis on pure, sexless, tranquil romance and on a peaceful, stable setting", but as the category expanded, other narrative and gameplay elements were introduced, including action/adventure, combat and plots in which "the heroine can ‘save the world’ and ‘get the guy’ at the same time".[1]Mc. Kenzie & Co (1. American Laser Games and Girl's Club (1. Philips Interactive were simulation games for girls developed and released in the US in the past. The first Japanese otome game to be officially translated and sold in English was the visual novel Yo- Jin- Bo in 2. PC. Since then there have been a small handful of releases increasing each year, including Hakuoki: Demon of the Fleeting Blossom for the PSP and 3. DS. The genre has many style elements in common with shōjo and josei manga,[1] and plotwise they are often similar to harem manga. There are also games targeted towards women that are focused on romance between men, called boys' love games(ボーイズラブゲーム,bōizu rabu gēmu), and sometimes there are Boys' Love elements in otome games, but the two genres are usually kept separate. Otome games that are released on console and handheld platforms contain no pornographic content, as companies such as Sony and Nintendo do not allow it. There are games released on a PC platform which are rated 1. Some games were originally released for the PC with pornographic content, and were later toned down and re- released for the PS2. Other common elements in otome games are the importance of voice acting,[1]CG stills, and a small epilogue or set scene at the end of the game when a character is successfully finished. Gameplay[edit]Traditionally, the goal of these games is to have the desired partner fall in love and have a relationship with the player character, but the requirements for gaining a "good end" differ from game to game. While the plots of otome games differ greatly, there is usually a single female main character, and several good- looking males of varying "types". Gameplay occasionally does not particularly focus on romance, even if there are several characters whose "routes" you can follow. In the visual novel examples of the genre, the player proceeds in the story by selecting dialogue or action choices which affect their relationships in a decision tree format. In simulation otome games, there is also other gameplay which affects the plot, either by playing minigames or by raising stats. The main character often has several parameters, such as looks, style, intelligence, talent, etc., that can be raised through various activities in normal gameplay. The potential partners usually require a certain parameter or parameters to be at a certain level for them to fall in love with you. There is also often a pure dating aspect of gameplay in simulations. This involves asking or being asked on dates by the love interest, doing an activity with them, and responding to their questions or comments. The player has a choice of responses, and a correct answer will raise your standing with that character. One feature that has become common in otome games is "full voice" (フルボイス,furu boisu), which is to have voice acting throughout the entire game. The love interests are often voiced by well- known voice actors. At certain points, or when the player passes certain requirements, special events can occur, often with a "CG" (computer graphic) as a reward. This CG is a set picture featuring the love interest and sometimes the main character in a pose, and some dialogue. Links with other media[edit]Otome games have strong links with shōjomanga, with popular titles often spawning a manga series (e. ![]() Young adult fiction - Wikipedia. Young adult fiction or young adult literature (YA)[1] is fiction published for readers in their youth. The age range for young adult fiction is subjective. Some sources claim it ranges from ages 1. Turning young adult novels into feature films has been all the rage this decade. Never has the prospect of adapting a YA novel to the. Books are listed according to their most recent publication dates (so newest in a series first, oldest last). To find out where to order any of Simon's. · Best Young Adult Novels, Best Teen Fiction, Top 100 Teen Novels More than 75,000 of you voted for your favorite young-adult fiction. Now, after all the. As well as sequels, remakes, and comic book adaptations, there’s one kind of movie you can feel fairly sure is going to keep popping up at a cinema near you: young. We've rounded up the young adult books worth checking out, no matter your age. Victoria Aveyard, whose debut novel, Red Queen, made her the first author to have her debut novel open at No. 1 on The New York Times young adult best-seller list. The terms young adult novel, juvenile novel, teenage fiction, young adult book, etc., refer to the works in this category.[4]The subject matter and story lines of young adult literature are typically consistent with the age and experience of the main character, but this literature spans the spectrum of fiction genres. Stories that focus on the specific challenges of youth are sometimes referred to as problem novels or coming- of- age novels.[5] According to 2. Tor Books, women outnumbered men by 6. History[edit]Beginning[edit]The history of young adult literature is tied to the history of how childhood and young adulthood has been perceived. The 1. 92. 0s "was the first time when it became clear that the young were a separate generation",[7] yet many novels within the young category had been published long before. One early writer to recognize young adults as a distinct group was Sarah Trimmer, who, in 1. In her children's literature periodical, The Guardian of Education, Trimmer introduced the terms "Books for Children" (for those under fourteen) and "Books for Young Persons" (for those between fourteen and twenty- one), establishing terms of reference for young adult literature that still remains in use.[8] Nineteenth century literature presents several early works, that appealed to young readers,[9] though not necessarily written for them, including The Swiss Family Robinson (1. Walter Scott's Waverley (1. Charles Dickens' Oliver Twist (1. Alexandre Dumas' The Count of Monte Cristo (1. Tom Brown's Schooldays (1. Dickens' Great Expectations (1. Alice in Wonderland (1. Mark Twain's The Adventures of Tom Sawyer (1. Adventures of Huckleberry Finn (1. Robert Louis Stevenson's Kidnapped (1. Rudyard Kipling's The Jungle Book (1. Moonfleet (1. 89. J. Meade Falkner.[citation needed]2. In the 1. 95. 0s, two influential adult novels, The Catcher in the Rye (1. Lord of the Flies (1. The modern classification of young- adult fiction originated during the 1. S. E. Hinton's The Outsiders (1. The novel featured a truer, darker side of adolescent life that was not often represented in works of fiction of the time. Written during high- school and published when Hinton was only 1. The Outsiders also lacked the nostalgic tone common in books about adolescents written by adults.[1. The Outsiders remains one of the best- selling young adult novels of all time.[1. The 1. 96. 0s became the era "when the 'under 3. It was also be the decade when literature for adolescents could be said to have come into its own".[1. This increased the discussions about adolescent experiences and the new idea of adolescent authors. In the late 1. 96. I Know Why the Caged Bird Sings (1. American poet Maya Angelou; The Friends (1. Rosa Guy; the semi- autobiographical The Bell Jar (US 1. UK 1. 96. 7) by poet Sylvia Plath; Bless the Beasts and Children (1. Glendon Swarthout; and Deathwatch (1. Robb White, which was awarded 1. Edgar Award for Best Juvenile Mystery by the Mystery Writers of America. The works of Angelou, Guy, and Plath were not written for young readers. As publishers began to focus on the emerging adolescent market, booksellers and libraries began creating young adult sections distinct from children's literature and novels written for adults. The 1. 97. 0s to the mid- 1. In the 1. 98. 0s, young adult literature began pushing the envelope in terms of the subject matter that was considered appropriate for their audience: Books dealing with topics such as rape, suicide, parental death, and murder which had previously been deemed taboo, saw significant critical and commercial success. This reflected a trend in British and American wanting to read stories that reflected the real word state of young people; A flip- side of this trend was a strong revived interest in the romance novel. Perhaps owing to this, the decade saw a noticeable dearth in fantasy literature from major publishers, even though fantasy titles such as Charlotte's Web and The Chronicles of Narnia had dominated sales in earlier decades.[1. By the 1. 99. 0s, many worried that the era of young adult literature was going to lose steam might ultimately prove to be a long- lived fad, however due a combination of a continued exploration of mature and controversial themes[1. In 1. 99. 7, J. K. Rowling's first Harry Potter novel, Harry Potter and the Philosopher's Stone was published. The first of the seven- book Harry Potter series, which was praised for its complexity and maturity, and attracted a wide adult audience. It was essentially about three adolescents trying to lead a normal life and cope with the banal struggles of coming of age and deal with their loss of innocence in an increasingly war- ridden 1. Britain. The success of the Harry Potter series led many to see Harry Potter and its author, J. Key Ingredients All Young Adult Novels Must Have. The young adult market is unyielding in popularity, at least for the foreseeable future, but this also means it’s a flooded market with content published daily. So the big question right now is how can an author stand out from the crowd? The answer is writing a seriously great YA novel. That may seem like the most common advice ever, right? Writing a good book should be the goal of all writers, but to hit the YA readers the hardest an author needs to make sure they are giving readers what they want and telling a good story at the same time. Great content gets noticed, and word of mouth is king in the publishing industry. Great content gets noticed, and word of mouth is king in the publishing industry. Click To Tweet. There are 5 key ingredients that, when carefully mixed together, create a brilliant young adult novel, and I’ll be addressing each of those in detail. Right, let’s get straight into it.#1 Unique voice/narration. The protagonist of a YA novel and the point of view (POV) we see the story told from is extremely important to connecting your readers with the character and story. The protagonist is either narrating the novel (in first person) or the POV is heavily close over his or her shoulder (limited third person) so we feel that the story is being told through our protagonist’s eyes. The best YA novels are the ones with a character that has a strong, unique voice. When I say a strong voice, I mean the protagonist’s voice is clearly defined so that a reader immediately feels like they know the character. Consider Hazel Lancaster, the protagonist in The Fault in Our Stars by John Green. Hazel’s witty, sarcastic, and endearing personality comes off immediately in the first pages of the novel as we discover her outlook on life, cancer, and the people that surround her. First person POV is mostly used in books with one protagonist and is very common in YA because of the close, one- sided vision which places readers in the character’s shoes. This is an example of reader- proxy—a character who stands in for the reader—which is crucial to YA novels. In The Fault in Our Starsthe entire novel is told through Hazel’s eyes, as if we are inside of her head. In first person, a reader knows the character’s unfiltered thoughts and emotions. This can make an extremely rewarding story, however, one of the caveats with this story telling is that readers do not get to see the point of view of other characters. There are some instances of YA novels told through dual first person narration, meaning we have two protagonists (who are usually also acting as the antagonists to each other), for example, June and Day in Legend by Marie Lu. In third person point of view it is likely the story will focus on multiple characters, anywhere between 2- 5, although 2- 3 is more common, as it’s easier to follow less characters. This form of narration can still be close, with the voice of the characters coming through the story. Harry Potter is told in third person because we do have a few scenes that take place where Harry isn’t present. However, in the scenes that Harry is present, his view of life, his friends, and the world around him is distinct and clear. In order for a reader to be invested, they need to connect to the character—care about him or her, and enjoy the unique ways the character views the world.#2 In teen years, not about teen years. This is an element that can easily be misunderstood in YA novels. Yes, young adult fiction is aimed at readers 1. But writing a story about teenagers and writing as story as a teenager is very different. A YA author must get into the head of the teenager and tell the story as a teen would tell it, with the voice of a teen, and the life experiences of a teen. Best- selling author Jodi Picoult co- wrote her YA novel, Between The Lines, with her daughter, which helped hone the voice of a teenage narrator. Picoult said of the experience, “Having a co- writer who was a teenager was like having a built- in B. S. meter sitting next to me.” Other writers suggest listening to teens talk, or interviewing them and asking if a situation, scene, or dialogue would ring true to them. As Veronica Roth, author of the Divergent trilogy says, “I think everyone’s got a little teenager inside of them still, and you just have to work to help yourself access that teenager.”The key thing to keep in mind when writing a YA novel is that there is no adult hindsight in young adult fiction. The story isn’t about reflection, it’s about the experience in that moment in a teenager’s life.#3 Simplicity in the prose. Writing a story in masterful, intricate prose is rewarding for a writer, but not for YA readers. Click To Tweet. Writing a story in masterful, intricate prose is rewarding for a writer, but not for YA readers. The beauty of a YA reader is that they will let you off the hook for writing that is more simple in nature, because the story and characters are the driving force in the story. Welcome to Enchanted Learning! Enchanted Learning. Enchanted Learning® produces children’s educational web sites which are designed to capture the imagination while maximizing creativity, learning, and enjoyment. Ease of use is a hallmark of our material. Children need the clearest, simplest computer interface, and our material is created so that the navigation and controls are intuitive. Our mission is to produce the best educational material, emphasizing creativity and the pure enjoyment of learning. 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